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A highly selective, cell-permeable indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor (IC = 70 nM) for murine vascular endothelial growth factor receptor 2 (VEGF-R2; KDR/Flk-1). The inhibition is suggested to be competitive with respect to ATP. Does not inhibit PDGFR, EGFR, and IGF-1 tyrosine kinase activities (IC 100 M).

Additional Information

Synonyms	(Z)-3-[(2,4-Dimethyl-3-(ethoxycarbonyl)pyrrol-5-yl)methylidenyl]indolin-2-one
Product #	V-1082
CAS #	15966-93-5
Chemical Name	(Z)-3-[(2,4-Dimethyl-3-(ethoxycarbonyl)pyrrol-5-yl)methylidenyl]indolin-2-one
Formula	C18H18N2O3
MW	310.4
Appearance	Yellow Solid
Purity	95%
Solubility	Soluble in DMSO (10 mg/ml) or Etahnol (1 mg/ml)
Storage Temp	-20°C
Use	A highly selective, cell-permeable indolin-2-one class of receptor tyrosine kinase

Additional Information

MDL Number	MFCD04974538
InChI	InChI=1S/C18H18N2O3/c1-4-23-18(22)16-10(2)15(19-11(16)3)9-13-12-7-5-6-8-14(12)20-17(13)21/h5-9,19H,4H2,1-3H3,(H,20,21)/b13-9-
SMILES	CCOC(=O)C1=C(NC(=C1C)/C=C\2/C3=CC=CC=C3NC2=O)C